Author

P. Sarkies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:comparative / phylogenetic analysis· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

E. A. Miska· 2 shared M. Tanguy· 2 shared A. Brown· 1 shared A. Ross· 1 shared A.-C. Zakrzewski· 1 shared B. Fromm· 1 shared C. Gilbert· 1 shared C. Glemas· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersEvolutionary Biology

E. A. Miska

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Author profile →

6 papers

Recent·Most cited

Identification of proteins that bind extracellular microRNAs secreted by the parasitic nematode Trichinella spiralis

P. Sarkies, M. E. Selkirk, A. Brown

The paper identifies two RNA-binding proteins secreted by Trichinella spiralis that bind miRNAs, suggesting a mechanism for their extracellular stability.

bioRxiv · May 29, 2023 · PreprintBiochemistry

The slow evolving genome of the xenacoelomorph worm Xenoturbella bocki

P. H. Schiffer, P. Natsidis, D. J. Leite, H. Robertson, F. Lapraz, F. Marletaz, B. Fromm, L. Baudry, F. Simpson, E. Hoye, A.-C. Zakrzewski, P. Kapli, K. J. Hoff, S. Mueller, M. Marbouty, , M. J. Telford

This study analyzes the genome of Xenoturbella bocki to assess its phylogenetic position and genomic complexity, finding it has a complex genome similar to other bilaterians.

bioRxiv · Jun 24, 2022 · PreprintEvolutionary Biology

Evolved changes in DNA methylation in response to the sustained loss of parental care in the burying beetle

R. Mashoodh, P. Sarkies, J. Westoby, R. M. Kilner

This study shows that loss of parental care in burying beetles leads to changes in DNA methylation and gene expression, shifting from stress-related pathways to growth and brain development after 30 generations.

bioRxiv · Mar 25, 2021 · PreprintEvolutionary Biology

CD8+ T-cell transcription and DNA methylation show age specific differences and lack correlation with clinical outcome in pediatric Inflammatory Bowel Disease

M. Gasparetto, F. Payne, K. Nayak, J. Kraiczy, C. Glemas, Y. Philip-McKenzie, A. Ross, R. D. Edgar, D. Zerbino, C. Salvestrini, F. Torrente, P. Sarkies, R. Heuschkel, M. Zilbauer

The paper examines CD8+ T-cell gene expression and DNA methylation in pediatric IBD patients, finding age-related differences but no correlation with clinical outcomes.

bioRxiv · Mar 30, 2020 · PreprintImmunology

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

S. H. Lewis, K. A. Quarles, Y. Yang, M. Tanguy, L. Frezal, S. A. Smith, P. P. Sharma, R. Cordaux, C. Gilbert, I. Giraud, D. H. Collins, P. D. Zamore, E. A. Miska, P. Sarkies, F. M. Jiggins

The paper analyzes piRNA pathways across 20 arthropod species, finding somatic piRNAs as an ancestral defense against transposable elements.

bioRxiv · Oct 4, 2017Evolutionary Biology

An alternative STAT signaling pathway acts in antiviral immunity in Caenorhabditis elegans

M. Tanguy, L. Veron, P. Stempor, J. Ahringer, P. Sarkies, E. A. Miska

The paper identifies a novel STAT signaling pathway in C. elegans that suppresses antiviral immunity, contrasting with the mammalian interferon system.

bioRxiv · Feb 25, 2017Immunology