M. Zilbauer

Reconstructing bat antiviral immunity using epithelial organoids

This study uses bat epithelial organoids to investigate antiviral immunity differences between bats and humans, revealing unique interferon responses and implications for viral pathogenesis.

PTEN and ARID1A haploinsufficiency equip colonic epithelium for oncogenic transformation

The paper investigates how PTEN and ARID1A haploinsufficiency in colonic epithelium contributes to oncogenic transformation by altering clone dynamics and creating a pro-tumorigenic microenvironment.

Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR

This study develops an efficient ribonucleoprotein-based CRISPR method for editing human intestinal organoids, achieving 98% editing efficiency with no off-target effects and revealing PTEN loss phenotypes.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

CD8+ T-cell transcription and DNA methylation show age specific differences and lack correlation with clinical outcome in pediatric Inflammatory Bowel Disease

The paper examines CD8+ T-cell gene expression and DNA methylation in pediatric IBD patients, finding age-related differences but no correlation with clinical outcomes.

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway and RNA Polymerase II mediated transcriptional responses.

This study shows that HuNoV replication in intestinal epithelial cells is restricted by IFN-induced transcriptional responses and that inhibiting these responses enhances viral replication.

The landscape of somatic mutation in normal colorectal epithelial cells

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.