Author

P. Valenzisi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:DNA methylation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Approach:wet-lab / biochemical assay· 2

Frequent Co-Authors

A. Franchitto· 5 shared P. Pichierri· 5 shared E. Malacaria· 2 shared M. Semproni· 2 shared V. Marabitti· 2 shared V. Palermo· 2 shared A. Noto· 1 shared A. Pellicioli· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCell Biology

A. Franchitto

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

V. Palermo, E. Malacaria, M. Semproni, B. Perdichizzi, P. Valenzisi, M. Sanchez, F. Marini, A. Pellicioli, A. Franchitto, P. Pichierri

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

bioRxiv · Feb 11, 2024Cell Biology

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

A. Noto, P. Valenzisi, F. Fratini, T. Kulikowicz, J. A. Sommers, F. Di Feo, V. Palermo, M. Semproni, M. Crescenzi, R. M. Brosh, A. Franchitto, P. Pichierri

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

WRNIP1 prevents transcription-associated genomic instability

P. Valenzisi, V. Marabitti, P. Pichierri, A. Franchitto

This study identifies WRNIP1 as a factor that prevents transcription-associated genomic instability by resolving R-loop conflicts and limiting DNA damage.

bioRxiv · Jun 23, 2023Cell Biology

RAD52 prevents accumulation of Polα-dependent replication gaps at perturbed replication forks

G. Marozzi, L. Di Biagi, E. Malacaria, M. Honda, P. Valenzisi, F. A. Aiello, M. Spies, A. Franchitto, P. Pichierri

This study shows RAD52 prevents Polα-dependent replication gaps by enabling RAD51/Pol repriming at reversed replication forks, which limits DNA damage and improves cell viability during replication stress.

bioRxiv · Apr 12, 2023 · PreprintCell Biology

WRNIP1 PREVENTS G4/R-LOOP-ASSOCIATED GENOMIC INSTABILITY

P. Valenzisi, V. Marabitti, S. Petrai, F. R. Giardinelli, P. Pichierri, A. Franchitto

This study identifies WRNIP1's role in preventing DNA damage caused by G4/R-loop-associated transcription-replication conflicts by stabilizing FANCJ at G4 sites.

bioRxiv · Dec 17, 2022 · PreprintCell Biology