Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice
J. Yang, Z. Zhang, Z. Xie, L. Bai, P. Xiong, F. Chen, T. Zhu, Q. Peng, H. Wu, Y. Zhou, Y. Ma, Y. Zhang, M. Chen, J. Gao, W. Tian, , K. Wang
This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.
bioRxiv · Sep 30, 2021Animal Behavior & Cognition