W. Tian

CASTpFold: Computed Atlas of Surface Topography of the universe of protein Folds

CASTpFold extends the CASTp tool to provide accurate and comprehensive protein surface topography analysis using AlphaFold2 structures and functional annotations.

The PCM scaffold enables RNA localization to centrosomes

The paper investigates how Plp mRNA localizes to centrosomes, showing that its coding sequence is necessary and sufficient for localization and that PCM scaffold interactions facilitate this process.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

A non-invasive, fast on/off 'Odourgenetic' Method to Manipulate Physiology

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain

Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with loss of proteostasis

The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

Next generation of anti-PD-L1 Atezolizumab with better anti-tumor efficacy in vivo

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

A chloride efflux transporter OsBIRG1 regulates grain size and salt tolerance in rice

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

The paper identifies and characterizes a novel adipocyte population with active Wnt/β-catenin signaling that influences beige fat formation and glucose homeostasis in mice.

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

Large-scale prediction of key dynamic interacting proteins in multiple cancers

The paper predicts key dynamic interacting proteins in multiple cancers and identifies their functional characteristics and network roles.

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

Chidamide decreases c-MET mRNA methylation and in turn increases the sensitivity of non-small cell lung cancer to crizotinib

This study shows chidamide reduces c-MET mRNA methylation, increasing NSCLC sensitivity to crizotinib, particularly in cells with high c-MET expression.

Mechanism and site of action of big dynorphin on ASIC1a

This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.

Disease mutation study identifies essential residues for phosphatidylserine flippase ATP11A

The paper identifies essential residues in ATP11A for its expression and flippase activity through mutation analysis and functional assays.

Loss of Sarm1 non-autonomously protects Schwann cells from chemotoxicity

This study shows that Sarm1 loss non-autonomously protects Schwann cells from chemotoxicity after neuronal injury in zebrafish.

In vitro Reconstitution Unveils the Phospho-regulated Ska-Ndc80 Macro-complex

This study identifies Cdk1 phosphorylation as essential for forming the Ska-Ndc80 macro-complex, crucial for chromosome segregation.

GeTFEP: A general transfer free energy profile of transmembrane proteins

This study develops GeTFEP, a transfer free energy profile for transmembrane proteins, showing its ability to predict membrane positioning, orientation, and important residue sites.