Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
L. F. Sobala, P. Z. Fernandes, Z. Hakki, A. J. Thompson, J. D. Howe, M. Hill, N. Zitzmann, S. Davies, Z. Stamataki, T. D. Butters, D. S. Alonzi, S. J. Williams, G. J. Davies
The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.
bioRxiv · Jun 30, 2020Biochemistry