S. J. Williams

AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition

The paper reports the crystal structure of AvrSr27, a Pgt effector, revealing its modular zinc-bound fold and its role in immune recognition by Sr27.

Plant pathogenic fungi hijack phosphate starvation signaling with conserved enzymatic effectors

This study identifies a family of fungal effectors that manipulate plant phosphate sensing to enhance pathogen virulence.

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

This study identifies LamH, a glycoside hydrolase that cleaves -1,6-mannoside linkages in LAM/LM, enabling their export to the capsule and promoting bacterial growth.

Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose

This paper identifies a novel bacterial pathway for sulfofucose catabolism in Paracoccus wurundjeri, involving a sulfofucolytic Entner-Doudoroff pathway and subsequent biomineralization to sulfite.

A broad-spectrum α-glucosidase of glycoside hydrolase family 13 from Marinovum sp., a member of the Roseobacter clade

The paper identifies and characterizes a broad-spectrum α-glucosidase from Marinovum sp., revealing its unexpected activity on various disaccharides rather than sulfosugars.

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum

This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.

Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis

The paper identifies two bacteria capable of degrading levoglucosan and analyzes their genome and proteome to understand the degradation pathway and related enzymes.

Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes

The paper identifies D-arabinan degrading enzymes in the human gut microbiome, including new families of glycoside hydrolases and mycobacterial enzymes involved in cell wall degradation.

An autoactive NB-LRR gene causes Rht13 dwarfism in wheat

The paper identifies Rht13, an autoactive NB-LRR gene that causes dwarfism in wheat, offering a new approach for semidwarfing in crops.

The structural repertoire of Fusarium oxysporum f. sp. lycopersici effectors revealed by experimental and computational studies

This study identifies a new structural class of fungal effectors in Fusarium oxysporum f. sp. lycopersici using experimental and computational methods, revealing structural relationships and immune recognition mechanisms.

Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway

The paper reports genome sequences of two gram-positive Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway to metabolize sulfoquinovose, producing sulfolactate as the end-product.

The necrotrophic effector ToxA from Parastagonospora nodorum interacts with wheat NHL proteins to facilitate Tsn1-mediated necrosis

This study identifies how the wheat protein TaNHL10 interacts with the effector ToxA to trigger cell death in wheat, revealing a key mechanism in necrotrophic pathogenesis.

Optimised production of disulfide-bonded fungal effectors in E. coli using CyDisCo and FunCyDisCo co-expression approaches

This paper improves the production of disulfide-bonded fungal effectors in E. coli using CyDisCo and FunCyDisCo co-expression systems, enabling functional studies and crystallisation.

Solar simulated ultraviolet radiation inactivates HCoV-NL63 and SARS-CoV-2 coronaviruses at environmentally relevant doses

This study investigates the inactivation of HCoV-NL63 and SARS-CoV-2 by solar-simulated ultraviolet light at environmentally relevant doses, finding that sUV exposure reduces viral infectivity and blocks stress responses.

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

This study identifies benzofuran sulfonates and small self-lipid antigens as activators of type II NKT cells via CD1d, revealing non-lipidic small molecules that trigger CD1d-restricted NKT cell responses.

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

This paper identifies a sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum that allows growth on sulfoquinovose, producing sulfolactate and contributing to bacterial persistence in soil.

Glutathione is Required for Efficient Post-Golgi Trafficking of Incoming HPV16 Genome

This study shows that glutathione (GSH) is necessary for efficient post-Golgi trafficking of HPV16 genome to the nucleus.

The metabolic repair enzyme phospho-glycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in Plasmodium falciparum

This study identifies phospho-glycolate phosphatase (PfPGP) as a regulator of central carbon metabolism in Plasmodium falciparum, showing its role in metabolite homeostasis and drug sensitivity.