Author

M. K. Mansour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

D. B. Sykes· 3 shared A. Hopke· 2 shared A. K. Scherer· 2 shared D. Irimia· 2 shared K. D. Timmer· 2 shared S. Xu· 2 shared A. Amir· 1 shared A. Anselmo· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

D. B. Sykes

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils

T. N. Huynh, J. Toperzer, A. Scherer, A. Gumina, T. Brunetti, M. K. Mansour, D. M. Markovitz, B. C. Russo

This study shows vimentin regulates neutrophil mitochondrial ROS production and inflammatory responses by modulating mitochondrial function and ROS levels.

bioRxiv · Apr 11, 2024Immunology

Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming

J. Strickland, D. Pan, C. Godfrey, J. S. Kim, A. Hopke, M. Degrange, B. Villavicencio, M. K. Mansour, C. S. Zerbe, D. Irimia, A. Amir, O. D. Weiner

The paper identifies a self-extinguishing relay wave mechanism in human neutrophils that controls swarming and recruitment levels through an NADPH-oxidase-based feedback loop.

bioRxiv · Jun 27, 2023Cell Biology

Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida

A. K. Scherer, A. Hopke, S. Xu, A. Viens, N. J. Alexander, K. D. Timmer, D. Archambault, D. Floyd, N. J. Atallah, C. Rhee, M. Cetinbas, D. Scadden, D. Irimia, D. B. Sykes, R. I. Sadreyev, M. K. Mansour

The paper shows that clonal neutrophil progenitors have predestined transcriptional and epigenetic heterogeneity that influences their response to Candida infections.

bioRxiv · Nov 1, 2022 · PreprintImmunology

The C-type Lectin Receptor Dectin-2 is a receptor for Aspergillus fumigatus galactomannan

J. L. Reedy, A. J. Crossen, P. E. Negoro, H. E. Brown, R. A. Ward, D. A. V. Blanco, K. D. Timmer, M. K. Mansour, M. Wüthrich, T. Fontaine, J.-P. Latgé, J. M. Vyas

This study identifies Dectin-2 as a receptor for Aspergillus fumigatus galactomannan, showing it mediates pro-inflammatory signaling and immune responses.

bioRxiv · Apr 12, 2022Immunology

Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells

P.-T. Dong, Y. Zhan, S. Jusuf, J. Hui, Z. Dagher, M. K. Mansour, J.-X. Cheng

This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.

bioRxiv · Aug 31, 2021Microbiology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

G. T. Nguyen, S. Xu, S. C. Bunnell, M. K. Mansour, D. B. Sykes, J. Mecsas

This study shows SKAP2 is essential for neutrophil ROS production in response to C-type lectin receptors and Candida infections, expanding its role beyond antibacterial immunity.

bioRxiv · Mar 2, 2021Immunology