Autophagy driven by VPS34 enables differentiated cell plasticity and cancer initiation
Fernanda Ramos‐Delgado, Hala Shalhoub, Camille Guyon, Charles Handschin, Pablo Cerapio-Arroyo, R. D’Angelo, N. Therville, Amélie V. Villard, Coralie Cayron, Carine Valle, Émeline Sarot, Nathalie Dusserre, Mickaël Di‐Luoffo, Vinciane Rebours, Anne Couvelard, , Julie Guillermet‐Guibert
This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.
bioRxiv · May 2, 2025 · PreprintPathology