B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure
Fang Chen, Erick Giang, Padmaja Natarajan, Tony S. Mondala, Steven Robert Head, Sing Chau Lau, Aishwarya Sundaresan, Liudmila Kulakova, Xiaohe Lin, Jasneet Aneja, Raiees Andrabi, Yun Zhang, Richard H. Scheuermann, Eric A. Toth, Thomas R. Fuerst, , Mansun Law
This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.
bioRxiv · Oct 24, 2025 · PreprintImmunology