Steven Robert Head

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.

B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure

This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.

Catalyzing computational biology research at an academic institute through an interest network

The paper describes how a volunteer-led affinity group enhances computational biology skills and networking among researchers at an academic institute.

A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

The paper introduces scCLEAN, a CRISPR/Cas9-based method to enhance single-cell transcriptomics by improving library complexity and isoform detection.

A Genome-wide Survey of Mutations in the Jurkat Cell Line

This study identifies and prioritizes damaging mutations in the Jurkat cell line using whole-genome sequencing and public databases, linking them to known expression defects.