Author

Sing Chau Lau

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Eric A. TothiD· 2 shared Erick Giang· 2 shared Georg M. LaueriD· 2 shared Mansun LawiD· 2 shared Thomas R. FuerstiD· 2 shared Aishwarya Sundaresan· 1 shared Arthur Y. KimiD· 1 shared Fang CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Eric A. TothORCID

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2 papers

Recent·Most cited

The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages

Fang Chen, Yen Thi Kim Nguyen, Yi-Zong Lee, Erick Giang, Sing Chau Lau, Yukiye Koide, Shr-Hau Hung, Lynn A. Ueno, Linling He, Eric A. Toth, Thomas R. Fuerst, Georg M. Lauer, Robyn L. Stanfield, Jiang Zhu, Ian A. Wilson, Mansun Law

This study identifies the conserved bridging domain on HCV E1E2 as a target for neutralizing antibodies from diverse lineages, showing additivity with neutralizing face antibodies.

Cell Reports · Aug 1, 2026Peer-reviewedImmunology

B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure

Fang Chen, Erick Giang, Padmaja Natarajan, Tony S. Mondala, Steven Robert Head, Sing Chau Lau, Aishwarya Sundaresan, Liudmila Kulakova, Xiaohe Lin, Jasneet Aneja, Raiees Andrabi, Yun Zhang, Richard H. Scheuermann, Eric A. Toth, Thomas R. Fuerst, , Mansun Law

This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.

bioRxiv · Oct 24, 2025 · PreprintImmunology