IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination
Alejandro Montilla, Alazne Zabala, Ibai Calvo, Paloma Mata, Irene Tomé, Mirjam Koster, Amanda Sierra, Susanne M. Kooistra, Federico Nicolás Soria, Bart J. L. Eggen, Olatz Fresnedo, José Andrés Fernández, Vanja Tepavčević, Carlos Matute, Marı́a Domercq
This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.
bioRxiv · Aug 14, 2023 · PreprintNeuroscience