Author

Mirjam Koster

University Medical Center GroningenORCID 0000-0002-9286-1486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Bart J. L. EggeniD· 2 shared Susanne M. KooistraiD· 2 shared Alazne Zabala· 1 shared Alejandro MontillaiD· 1 shared Amanda SierraiD· 1 shared Anneke MiedemaiD· 1 shared Astrid M. AlsemaiD· 1 shared Carlos MatuteiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Bart J. L. EggenORCID

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2 papers

Recent·Most cited

Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics

Anneke Miedema, Marion H. C. Wijering, Astrid M. Alsema, Emma Gerrits, Michel Meijer, Mirjam Koster, Evelyn M. Wesseling, Wia Baron, Bart J. L. Eggen, Susanne M. Kooistra

This paper uses spatial transcriptomics to identify regional astrocyte heterogeneity in cuprizone-induced demyelination and remyelination, revealing differential gene expression patterns across brain regions.

bioRxiv · Mar 4, 2024 · PreprintNeuroscience

IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination

Alejandro Montilla, Alazne Zabala, Ibai Calvo, Paloma Mata, Irene Tomé, Mirjam Koster, Amanda Sierra, Susanne M. Kooistra, Federico Nicolás Soria, Bart J. L. Eggen, Olatz Fresnedo, José Andrés Fernández, Vanja Tepavčević, Carlos Matute, Marı́a Domercq

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

bioRxiv · Aug 14, 2023 · PreprintNeuroscience