Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration
Marije Been, Erwan Lambert, Ana Serna, Anouk C. G. Balvert, Simon Heisinger, Merli Kreshpani, Catherine te Dorsthorst-Maas, Paulina Paškevičiūtė, Henar Rodríguez Arias, Danique Beijer, Galuh Astuti, Kevin Patrick Kenna, Boyd van Reijmersdal, Sharon Gloudemans, Pascal van Lith, , Erik Storkebaum
This study identifies excessive RAS/MAPK pathway activation as a cause of adult-onset motor axonal degeneration in Drosophila, showing that inhibiting the pathway can rescue neurodegenerative phenotypes.
iScience · Sep 21, 2026Peer-reviewedNeuroscience