Boyd van Reijmersdal

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

This study identifies excessive RAS/MAPK pathway activation as a cause of adult-onset motor axonal degeneration in Drosophila, showing that inhibiting the pathway can rescue neurodegenerative phenotypes.

The evolutionarily conserved EHMT1/G9a histone methyltransferase family regulates sleep maintenance through ROS homeostasis in insulin-producing cells

This study identifies EHMT1/G9a's role in sleep regulation through ROS homeostasis in insulin-producing cells, linking it to sleep disturbances in Kleefstra syndrome and common insomnia.

Polyamine dysregulation converges with RASopathies on RAS/MAPK and sensory processing phenotypes in Drosophila

The paper identifies polyamine metabolism genes that converge with RASopathies on RAS/MAPK and sensory processing phenotypes in Drosophila.

A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism

The paper identifies a conserved gene co-expression module in Drosophila linked to epilepsy, showing metabolic rate and AMPK activity influence seizure susceptibility.