Zoya Ignatova

ADAM-tRNA-seq improves demultiplexing and mapping accuracy in direct tRNA sequencing by addressing sequence similarity and multimapping issues.

The paper identifies tRNAGly sequestration as a unifying mechanism causing GARS1-associated peripheral neuropathy and suggests therapeutic strategies to elevate tRNAGly levels.

This paper uses adaptive laboratory evolution to replace tryptophan in E. coli with a synthetic analog, revealing that stress response inhibition, not translation rigidity, limits genetic code expansion.

The paper designs synthetic sRNAs to dynamically modulate gene expression in E. coli without altering existing genetic circuits.

The paper shows that Not1 and Not4 oppositely regulate mRNA solubility, affecting co-translational dynamics in yeast.

This study shows that endogenous proteolysis systems in E. coli are more efficient than foreign ones for improving cellular robustness under nutrient stress.

smORFer detects small ORFs in prokaryotes using a modular algorithm that integrates structural features and Fourier transform for accurate identification.

The paper presents a proteogenomics workflow to identify small proteins in Staphylococcus aureus, finding 185 SP100, 69 of which were previously unannotated.

The paper shows Not4 and Not5 regulate translation initiation and elongation differently, affecting codon-dependent ribosome behavior and translation efficiency.

The paper combines Ribo-seq and RNA-seq to quantify translation initiation rates, termination efficiencies, and frameshifting in E. coli, revealing insights into translational regulation and stress responses.

The paper presents cryo-EM structures of hibernating 70S and 100S ribosomes from E. coli, revealing the roles of HPF and RMF in ribosome inactivation and dimerization.

The paper identifies m6A methylation in the 5' vicinity of transcripts as a mechanism for directing mRNAs to stress granules via YTHDF3 recognition during oxidative stress.