Author

Paul Varley

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Diane HattoniD· 3 shared Johan RockbergiD· 3 shared Magdalena MalmiD· 3 shared Magnus LundqvistiD· 3 shared Anna-Luisa VolkiD· 2 shared Chih‐Chung Kuo· 2 shared David KotoliD· 2 shared Fredrik EdforsiD· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Diane HattonORCID

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3 papers

Recent·Most cited

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

Magdalena Malm, Chih‐Chung Kuo, Mona Moradi Barzadd, Aman Mebrahtu, Num Wistbacka, Ronia Razavi, Anna-Luisa Volk, Magnus Lundqvist, David Kotol, Hanna Tegel, Sophia Hober, Fredrik Edfors, Torbjörn Gräslund, Véronique Chotteau, Ray P. Field, , Johan Rockberg

The paper identifies secretory pathway differences between HEK293 and CHO cells that improve recombinant protein expression when switching hosts.

Metabolic Engineering · Mar 14, 2022Peer-reviewedSystems Biology

Evolution from adherent to suspension - systems biology of HEK293 cell line development

Magdalena Malm, Rasool Saghaleyni, Magnus Lundqvist, Marco Giudici, Véronique Chotteau, Ray P. Field, Paul Varley, Diane Hatton, Luigi Grassi, Thomas Svensson, Mathias Uhlén, Jens Nielsen, Johan Rockberg

The paper analyzes genomic, transcriptomic, and metabolic changes in HEK293 cell lines to understand genetic and compositional differences between adherent and suspension derivatives.

Scientific Reports · Nov 4, 2020Peer-reviewedSystems Biology

The human secretome - the proteins secreted from human cells

Mathias Uhlén, Hanna Tegel, Åsa Sivertsson, Chih‐Chung Kuo, Jahir M. Gutierrez, Nathan E. Lewis, Björn Forsström, Melanie Dannemeyer, Linn Fagerberg, Magdalena Malm, Helian Vunk, Fredrik Edfors, Andreas Hober, Evelina Sjöstedt, David Kotol, , Sophia Hober

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.

bioRxiv · Nov 27, 2018 · PreprintMolecular Biology