An atypical E3 ligase safeguards the ribosome during nutrient stress
Todd Douglas, Pengju Nie, Jiasheng Zhang, Kyrillos Abdallah, Zhiping Wu, Meghan G. McReynolds, Kazuhiro Iwaï, Junmin Peng, Wendy V. Gilbert, Lawrence H. Young, Craig M. Crews
This study identifies HOIL-1 as an atypical E3 ligase that protects the ribosome during nutrient stress, revealing a new signaling pathway involved in cell fate decisions.
Nature Cell Biology · Apr 30, 2026Peer-reviewedCell Biology