Author

Pengxiang Shen

Harvard University

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Amanda K. WilliamsoniD· 1 shared Andrew C. KruseiD· 1 shared Chérine BecharaiD· 1 shared Daniel Kahne· 1 shared James Osei‐OwusuiD· 1 shared Jeffrey S. SmithiD· 1 shared Mark W. GrinstaffiD· 1 shared Sarah C. Erlandson· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Amanda K. WilliamsonORCID

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1 paper

Recent·Most cited

Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists

James Osei‐Owusu, Tristan Girbau, Xunan Wang, Jeffrey S. Smith, Pengxiang Shen, Sarah C. Erlandson, Amanda K. Williamson, Xiaojing Cong, Mark W. Grinstaff, Daniel Kahne, Chérine Bechara, Andrew C. Kruse

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

bioRxiv · Jun 11, 2026 · PreprintBiochemistry