Multi-ContrastiveVAE disentangles perturbation effects in single cell images from optical pooled screens
Zitong Jerry Wang, Romain Lopez, Jan-Christian Hütter, Takamasa Kudo, Heming Yao, Philipp Hanslovsky, Burkhard Höckendorf, Rahul Moran, David Richmond, Aviv Regev
The paper introduces a contrastive analysis framework to disentangle perturbation effects from natural cell variation in optical pooled screens, showing improved performance in generating embeddings and reducing technical artifacts.
bioRxiv · Nov 28, 2023 · PreprintBioinformatics