Discovery and characterization of UCB-1A: the first PET radioligand for imaging synaptic vesicle glycoprotein 2C
Sangram Nag, Vasco C. Sousa, Anton Forsberg Morén, Miklós Tóth, Yasir Khani Meynaq, Elena Pedergnana, Rongfeng Zou, Anne Valade, Céline Vermeiren, Philippe Motté, Joël Mercier, Xiaoqun Zhang, Per Svenningsson, Hans Ågren, Christer Halldin, Andrea Varrone
This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.
bioRxiv · Mar 10, 2026 · PreprintNeuroscience