In silico evaluation of the effects of temperature on the affinity of the SV2C ligand UCB-1A to SV2 isoforms
Rongfeng Zou, Sangram Nag, Vasco C. Sousa, Anton Forsberg Morén, Miklós Tóth, Yasir Khani Meynaq, Elena Pedergnana, Anne Valade, C. Vermeiren, P. Motte, J Mercier, Xiaoqun Zhang, Per Svenningsson, Christer Halldin, Andrea Varrone, Hans Ågren
This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.
bioRxiv · Mar 21, 2026 · PreprintBiochemistry