Author

Xiaoqun Zhang

Karolinska InstitutetORCID 0000-0002-9461-8682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1

Frequent Co-Authors

Per SvenningssoniD· 3 shared Andrea VarroneiD· 2 shared Anne Valade· 2 shared Anton Forsberg Morén· 2 shared Christer HalldiniD· 2 shared Elena PedergnanaiD· 2 shared Hans ÅgreniD· 2 shared Miklós TóthiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Per SvenningssonORCID

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3 papers

Recent·Most cited

In silico evaluation of the effects of temperature on the affinity of the SV2C ligand UCB-1A to SV2 isoforms

Rongfeng Zou, Sangram Nag, Vasco C. Sousa, Anton Forsberg Morén, Miklós Tóth, Yasir Khani Meynaq, Elena Pedergnana, Anne Valade, C. Vermeiren, P. Motte, J Mercier, Xiaoqun Zhang, Per Svenningsson, Christer Halldin, Andrea Varrone, Hans Ågren

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

bioRxiv · Mar 21, 2026 · PreprintBiochemistry

Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder

Daniel Dautan, Wojciech Pasławski, Sergio Montejo, Daniel C. Doyon, Valentina I. Brioschi, Roberta Marongiu, Michael G. Kaplitt, Rong Chen, Valina Lynn Dawson, Xiaoqun Zhang, Ted M. Dawson, Per Svenningsson

This study shows that gut-to-brain propagation of alpha-synuclein fibrils induces REM sleep behavior disorder and other non-motor and motor Parkinson's disease phenotypes.

Translational Neurodegeneration · Mar 10, 2026Peer-reviewedNeuroscience

Discovery and characterization of UCB-1A: the first PET radioligand for imaging synaptic vesicle glycoprotein 2C

Sangram Nag, Vasco C. Sousa, Anton Forsberg Morén, Miklós Tóth, Yasir Khani Meynaq, Elena Pedergnana, Rongfeng Zou, Anne Valade, Céline Vermeiren, Philippe Motté, Joël Mercier, Xiaoqun Zhang, Per Svenningsson, Hans Ågren, Christer Halldin, Andrea Varrone

This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.

bioRxiv · Mar 10, 2026 · PreprintNeuroscience