Mechanisms regulating combination effect of antibody-drug conjugates and cancer immunotherapy
Şehmus Tohumeken, Ali Mostafa, Rashmi Binjawadagi, Mimi Mai, Ana Paucarmayta, Ana Maria Mansilla, Christine Youn, E Sally Chang, Pooja Shah, Huiyanangel Chow, Wileashire Moulton, Xiaokang Luo, Kerlene Berwick Tam, Matthew Flynn, Leslie K. Wetzel, , Dmitry I. Gabrilovich
This paper investigates the mechanisms of ADC-immunotherapy combinations, finding that ADC-induced autophagy upregulates TNFR and M6PR, driving antitumor effects through TNF and granzyme B pathways.
bioRxiv · Jul 22, 2026 · PreprintImmunology