Author

Christine Youn

AstraZeneca (United States)ORCID 0000-0002-0022-2848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Ali MostafaiD· 1 shared Ana Maria MansillaiD· 1 shared Ana PaucarmaytaiD· 1 shared Ang LiiD· 1 shared Anna HuntleyiD· 1 shared Bilal A. OmariD· 1 shared Brittany PielstickiD· 1 shared Carolina Mendoza-Topaz· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Ali MostafaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mechanisms regulating combination effect of antibody-drug conjugates and cancer immunotherapy

Şehmus Tohumeken, Ali Mostafa, Rashmi Binjawadagi, Mimi Mai, Ana Paucarmayta, Ana Maria Mansilla, Christine Youn, E Sally Chang, Pooja Shah, Huiyanangel Chow, Wileashire Moulton, Xiaokang Luo, Kerlene Berwick Tam, Matthew Flynn, Leslie K. Wetzel, , Dmitry I. Gabrilovich

This paper investigates the mechanisms of ADC-immunotherapy combinations, finding that ADC-induced autophagy upregulates TNFR and M6PR, driving antitumor effects through TNF and granzyme B pathways.

bioRxiv · Jul 22, 2026 · PreprintImmunology

Neutrophil extracellular traps impair regeneration

Eric M. Wier, Mayumi Asada, Gaofeng Wang, Martin Prince Alphonse, Ang Li, Chase Hintelmann, Evan Sweren, Christine Youn, Brittany Pielstick, Roger V. Ortines, Chenyi Lyu, Maria Daskam, Lloyd S. Miller, Nathan K. Archer, Luis Andres Garza

The paper shows that mature neutrophils and their extracellular traps inhibit wound-induced hair follicle regeneration despite being stimulated by a pro-regenerative cue.

Journal of Cellular and Molecular Medicine · Oct 8, 2021Peer-reviewedDevelopmental Biology