High Incidence of Estrous Cycle Irregularities in Heterogeneous Stock (HS) Rats is Associated with Severe Cocaine Addiction-like Behaviors
Elizabeth A. Sneddon, Supakorn Chonwattanagul, Kathleen Bai, Pranav H. Kurup, Sonja Lorean Plasil, Michelle R. Doyle, Sélène Bonnet-Zahedi, Sierra Simpson, Benjamin C. Sichel, Dyar N. Othman, Molly Brennan, Abraham A. Palmer, Marsida Kallupi, Lieselot L. G. Carrette, Giordano de Guglielmo, Olivier George
This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.
bioRxiv · Mar 6, 2025 · PreprintNeuroscience