INTERLEUKIN-18 AS A THERAPEUTIC TARGET FOR WESTERN DIET-INDUCED CARDIOMYOPATHY
Pratyush Narayan, Salvatore Carbone, Adolfo Gabriele Mauro, Eleonora Mezzaroma, Antonio Abbate, Stefano A Toldo
This study shows that blocking IL-18 with IL-18BP improves cardiac function in mice on a Western diet, independent of weight gain and glucose tolerance.
bioRxiv · Sep 23, 2025 · PreprintPhysiology