Scott Paterson

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish

This study shows that mural cells are not required for BBB function in developing zebrafish but protect against hemorrhage-induced BBB breakdown in adults.

Target RNA abundance controls the collateral activity of RfxCas13d in human cells and zebrafish embryos

This study shows that target RNA abundance controls collateral activity of RfxCas13d in human cells and zebrafish embryos, with high abundance causing widespread degradation and toxicity.

Integrin β1-Talin1 at focal adhesions underpin uncontrolled endothelial cell enlargement in live cerebral cavernous malformation vasculature

This study shows integrin β1-Talin1 at focal adhesions drive uncontrolled endothelial cell enlargement in CCM vasculature, independent of KLF2/4.

Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs

This study identifies HOPX as a molecular switch regulating cardiomyocyte progenitor and maturation gene programs, linking it to cardiac function and genetic variation.

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

This study uses a zebrafish Erk biosensor to live-image dynamic Erk-signalling events during regenerative angiogenesis, revealing sequential Ca2+- and Vegfr-dependent mechanisms.