A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain
Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph Steven Baric, Barton F. Haynes, Derek W. Cain, Timothy Patrick Sheahan, Daniel Wrapp
This study isolates and characterizes neutralizing antibodies against HCoV-229E, showing one antibody induces conformational changes in the viral spike protein.
Communications Biology · Dec 31, 2025Peer-reviewedImmunology