Discovery of ARQ-501 as a potent PafA inhibitor that elevates KatG levels to potentiate isoniazid in mycobacteria
Cong Li, Bingzhou Huang, Hang Xiong, Qiaohua Yan, Yan Liu, Cuiting Fang, Youfu Luo, Peng Xu, Ting Luo, Qingxiang Sun
The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.
bioRxiv · Jun 3, 2026 · PreprintMicrobiology