R. A. Boon

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

Impaired H19 lncRNA expression contributes to the compromised developmental angiogenesis in EVL-deficient mice

The paper shows that reduced H19 lncRNA expression in EVL-deficient mice impairs VEGF expression and bioavailability, leading to compromised angiogenesis in the retina.

Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases

The paper develops an artery-on-a-chip model to study shear stress effects on vascular diseases and identifies novel therapeutic targets.

Unravelling the impact of aging on the human endothelial lncRNA transcriptome

This study identifies age-related changes in lncRNA expression in human endothelial cells, highlighting PCAT14 as a key regulator of endothelial function and aging.

Aging-regulated TUG1 is dispensable for endothelial cell function

This study shows that TUG1, despite high expression and conservation, does not significantly affect endothelial cell function in vitro.