G. E. Janssens

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

Human ovarian ageing is characterized by oxidative damage and mitochondrial dysfunction

This study identifies oxidative damage and mitochondrial dysfunction in human oocytes during ovarian ageing using immunofluorescence, metabolomics, and lipidomics.

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

This study shows that reducing Mrpl54 expression in mice decreases mitochondrial-encoded protein content but does not improve metabolic health or lifespan.

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

This study shows aging reduces lipid oscillations in adipose tissues, with BAT showing specific acyl chain length-dependent rhythms lost in older mice.

Metabolomics and lipidomics in C. elegans using a single sample preparation

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging

The paper uses transcriptomics to screen for aging-deferring compounds, identifying Hsp90 inhibitors as potential geroprotectors.