Author

K. J. Menzies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Vasam· 3 shared A. E. Green· 2 shared D. Ryu· 2 shared E. G. Daniels· 2 shared E. Katsyuba· 2 shared G. E. Janssens· 2 shared H. Zhang· 2 shared J. Auwerx· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

G. Vasam

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

A. Tammaro, E. G. Daniels, I. M. Hu, K. C. t Hart, K. Reid, R. P. Juni, L. Butter, G. Vasam, R. S. Kamble, A. Jongejan, R. I. Aviv, J. J. T. H. Roelofs, E. Aronica, R. A. Boon, K. J. Menzies, , G. E. Janssens

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

bioRxiv · Aug 29, 2023 · PreprintPathology

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

K. Reid, E. G. Daniels, G. Vasam, R. Kamble, G. E. Janssens, M. Hu, A. E. Green, R. H. Houtkooper, K. J. Menzies

This study shows that reducing Mrpl54 expression in mice decreases mitochondrial-encoded protein content but does not improve metabolic health or lifespan.

bioRxiv · Nov 5, 2022 · PreprintCell Biology

Inhibition of GCN5 decreases skeletal muscle fat metabolism during high fat diet feeding

A. Green, B. L. Perras, H. Zhang, E. Katsyuba, A. Haboush, K. M. Nyarko, D. K. Pandey, A. Nik-Akhtar, D. Ryu, K. J. Menzies, J. Auwerx

This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.

bioRxiv · Oct 18, 2022 · PreprintPhysiology

GCN5 Maintains Muscle Integrity by Acetylating YY1 to Promote Dystrophin Expression

G. C. Addicks, H. Zhang, D. Ryu, G. Vasam, P. L. Marshall, A. E. Green, S. Patel, B. E. Kang, D. Kim, E. Katsyuba, E. G. Williams, J.-M. Renaud, J. Auwerx, K. J. Menzies

This study shows GCN5 acetylates YY1, reducing its DNA binding and increasing dystrophin expression, which maintains muscle integrity in mice.

bioRxiv · Mar 29, 2021Cell Biology