K. A. Jacobs

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

This study shows that MALT1 regulates cholesterol homeostasis in glioblastoma stem-like cells by shaping the lysosome proteome, leading to cell death when disrupted.

Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion

This study shows Notch1 cortical signaling, independent of transcription, regulates epithelial architecture and cell-cell adhesion by stabilizing adherens junctions and cortical actin.

The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma

This study identifies MLKL as a regulator of EV release from GSCs, showing its role in promoting tumour growth and suggesting EV targeting as a therapeutic strategy.

Control of the Endo-Lysosome Homeostasis by the Paracaspase MALT1 regulates Glioma Cell Survival

This study shows that MALT1 regulates endo-lysosome homeostasis and glioma cell survival, with MALT1 inhibition leading to lysosomal-mediated cell death.