Author

L. F. Stead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Assay:bulk RNA-seq· 6 Organism:human· 6 Research Focus:differential expression· 5 Approach:experimental assay· 5 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2

Frequent Co-Authors

A. Droop· 4 shared A. Bruning-Richardson· 3 shared A. Chakrabarty· 3 shared A. Ismail· 3 shared F. S. Varn· 3 shared G. Tanner· 3 shared S. C. Short· 3 shared A. Brodbelt· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCancer Biology

A. Droop

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

S. A. Ajaib, D. Lodha, S. Pollock, G. Hemmings, M. Finetti, A. Gusnanto, A. Chakrabarty, A. Ismail, E. Wilson, F. S. Varn, B. Hunter, A. Filby, A. A. Brockman, D. McDonald, R. Verhaak, , L. F. Stead

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

Neuro-Oncology · Jul 6, 2023Peer-reviewedCancer Biology

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

G. Tanner, R. Barrow, M. Finetti, S. Ajaib, N. Ahmed, S. Pollock, N. Rippaus, A. F. Bruns, K. Syed, J. Poulter, E. A. Wilson, C. A. Johnson, F. S. Varn, A. Bruning-Richardson, C. Hogg, , L. F. Stead

This study identifies two IDHwt glioblastoma subtypes based on transcriptional response to treatment, with distinct resistance mechanisms and potential therapeutic implications.

bioRxiv · Feb 3, 2023Cancer Biology

SpheroidAnalyseR - an online platform for analysing data from 3D spheroids or organoids grown in 96-well plates

R. Barrow, J. N. Wilkinson, Y. He, M. Callaghan, A. Bruning-Richardson, M. Dunning, L. F. Stead

SpheroidAnalyseR is an R Shiny app that enables fast, automated analysis of 3D spheroid or organoid growth data from 96-well plates, improving efficiency and reproducibility.

bioRxiv · Feb 18, 2022Cell Biology

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

F. S. Varn, K. C. Johnson, T. E. Wade, T. M. Malta, T. S. Sabedot, F. P. Barthel, H. Kim, N. Ahmed, I. Datta, J. S. Barnholtz-Sloan, S. Bakas, F. D'Angelo, H. K. Gan, L. Garofano, J. T. Huse, , The GLASS Consortium

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

bioRxiv · May 3, 2021Cancer Biology

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

A. Golebiewska, A.-C. Hau, A. Oudin, D. Stieber, Y. A. Yabo, V. Baus, V. Barthelemy, E. Klein, S. Bougnaud, O. Keunen, M. Wantz, A. Michelucci, V. Neirinckx, A. Muller, T. Kaoma, , S. P. Niclou

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

bioRxiv · Apr 24, 2020Cancer Biology

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

H. J. Close, L. F. Stead, J. Nsengimana, K. Reilly, A. Droop, H. Wurdak, R. K. Mathew, R. Corns, J. A. Newton-Bishop, A. A. Melcher, S. C. Short, G. P. Cook, E. B. Wilson

bioRxiv · Oct 4, 2019Immunology

JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatment

N. Rippaus, A. F-Bruns, G. Tanner, C. Taylor, A. Droop, A. Bruning-Richardson, M. A. Care, J. Wilkinson, M. D. Jenkinson, A. Brodbelt, A. Chakrabarty, A. Ismail, S. C. Short, L. F. Stead

The paper identifies JARID2-mediated transcriptional reprogramming in glioblastoma post-treatment, showing dysregulated genes with JARID2 binding sites are universally altered in recurrent tumors.

bioRxiv · Jun 17, 2019 · PreprintCancer Biology

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

B. da Silva, E. S. Polson, A. Droop, R. K. Mathew, L. F. Stead, J. Williams, S. C. Short, M. Scarcia, G. Mavria, H. Wurdak

The paper shows that ROCKi promotes neurite-like outgrowth in GBM cells, forming radiation-resistant multicellular networks that can be reversed.

bioRxiv · Nov 10, 2018Cancer Biology