Author

A. R. Greenplate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Research Focus:cell type annotation· 8 Research Focus:differential expression· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:flow cytometry· 4 Research Focus:clustering· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

E. J. Wherry· 8 shared A. E. Baxter· 7 shared D. Mathew· 7 shared J. Dougherty· 7 shared J. R. Giles· 7 shared A. Pattekar· 6 shared O. Kuthuru· 6 shared S. E. Hensley· 6 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersImmunology

E. J. Wherry

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Author profile →

10 papers

Recent·Most cited

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

M. M. Painter, T. S. Johnston, K. A. Lundgreen, J. J. S. Santos, J. S. Qin, R. R. Goel, S. A. Apostolidis, D. Mathew, B. Fulmer, J. C. Williams, M. L. McKeague, A. Pattekar, A. Goode, S. Nasta, A. E. Baxter, , E. J. Wherry

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

bioRxiv · Feb 5, 2023 · PreprintImmunology

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

C. E. Gustafson, Z. Thomson, Z. He, E. Swanson, K. Henderson, M.-P. L. Pebworth, L. Y. Okada, A. T. Heubeck, C. R. Roll, V. Hernandez, M. D. Weiss, P. C. Genge, J. Reading, J. R. Giles, S. Manne, , P. J. Skene

The study identifies age-related differences in naive T cell compartments between children and adults, showing distinct molecular reprogramming in CD4 and CD8 subsets.

bioRxiv · Oct 4, 2022 · PreprintImmunology

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Y. Muroyama, S. Manne, N. Wellhausen, D. A. Oldridge, A. R. Greenplate, L. Chilukuri, D. Mathew, C. Xu, R. S. Herati, S. L. Berger, A. C. Huang, C. H. June, D. Zamarin, C. F. Friedman, E. J. Wherry

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

bioRxiv · Apr 16, 2022 · PreprintImmunology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

R. R. Goel, M. M. Painter, K. A. Lundgreen, S. A. Apostolidis, A. E. Baxter, J. R. Giles, D. Mathew, A. Pattekar, A. Reynaldi, D. S. Khoury, S. Gouma, P. Hicks, S. Dysinger, A. Hicks, H. Sharma, , E. J. Wherry

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

bioRxiv · Feb 20, 2022Immunology

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

M. M. Painter, D. Mathew, R. R. Goel, S. A. Apostolidis, A. Pattekar, O. Kuthuru, A. E. Baxter, R. S. Herati, D. A. Oldridge, S. Gouma, P. Hicks, S. Dysinger, K. A. Lundgreen, L. Kuri-Cervantes, S. Adamski, , E. J. Wherry

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

bioRxiv · Apr 21, 2021 · PreprintImmunology

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

Z. Chen, E. Arai, O. Khan, Z. Zhang, S. F. Ngiow, Y. He, H. Huang, S. Manne, Z. Cao, A. E. Baxter, Z. Cai, E. Freilich, M. A. Ali, J. R. Giles, J. E. Wu, , J. Shi

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

bioRxiv · May 20, 2020 · PreprintImmunology

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D. Mathew, J. R. Giles, A. E. Baxter, A. R. Greenplate, J. E. Wu, C. Alanio, D. A. Oldridge, L. Kuri-Cervantes, M. B. Pampena, K. D'Andrea, S. Manne, Z. Chen, Y. J. Huang, J. P. Reilly, A. R. Weisman, , E. J. Wherry

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

bioRxiv · May 20, 2020Immunology

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

L. Kuri-Cervantes, M. B. Pampena, W. Meng, A. M. Rosenfeld, C. A. G. Ittner, A. R. Weisman, R. Agyekum, D. Mathew, A. E. Baxter, L. Vella, O. Kuthuru, S. Apostolidis, L. Bershaw, J. Dougherty, A. R. Greenplate, , M. R. Betts

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

bioRxiv · May 18, 2020 · PreprintImmunology

High risk glioblastoma cells revealed by machine learning and single cell signaling profiles

N. Leelatian, J. Sinnaeve, A. M. Mistry, S. M. Barone, K. E. Diggins, A. R. Greenplate, K. D. Weaver, R. C. Thompson, L. B. Chambless, B. C. Mobley, R. A. Ihrie, J. M. Irish

This paper introduces RAPID, an unsupervised machine learning algorithm that identifies single cell phenotypes and assesses clinical risk stratification in glioblastoma patients using single cell mass cytometry data.

bioRxiv · Jun 1, 2019Cancer Biology