Author

R. A. Saunders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

J. S. Weissman· 2 shared A. A. Anand· 1 shared A. A. Pollen· 1 shared A. F. Brilot· 1 shared A. Guna· 1 shared A. J. Inglis· 1 shared A. M. Smith· 1 shared A. N. Rizo· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

J. S. Weissman

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Author profile →

4 papers

Recent·Most cited

Triaging of -helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

G. Muthukumar, T. A. Stevens, A. J. Inglis, T. K. Esantsi, R. A. Saunders, F. Schulte, R. M. Voorhees, A. Guna, J. S. Weissman

The paper identifies distinct chaperone machinery for targeting mitochondrial outer membrane -helical proteins based on their topology using CRISPRi screens and biochemical analysis.

bioRxiv · Aug 16, 2023Cell Biology

Comparative landscape of genetic dependencies in human and chimpanzee stem cells

R. She, T. Fair, N. K. Schaefer, R. A. Saunders, B. J. Pavlovic, J. S. Weissman, A. A. Pollen

The paper compares genetic dependencies in human and chimpanzee stem cells, identifying 75 species-specific genes affecting cellular proliferation and supporting the G1-phase length hypothesis in human brain evolution.

bioRxiv · Mar 19, 2023Evolutionary Biology

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

M. Schoof, B. Faust, R. A. Saunders, S. Sangwan, V. V. Rezelj, N. Hoppe, M. Boone, C. Billesboelle, C. Puchades, C. M. Azumaya, H. T. Kratochvil, M. Zimanyi, I. Deshpande, J. Liang, S. Dickinson, , Barile-H

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

bioRxiv · Aug 8, 2020Biochemistry

Multistep substrate binding and engagement by the AAA+ ClpXP protease

R. A. Saunders, B. M. Stinson, T. A. Baker, R. T. Sauer

This study investigates the multistep binding and engagement of ssrA-tagged substrates by E. coli ClpXP using fluorescence-quenching assays and kinetic analysis, revealing a model of substrate recognition and unfolding.

bioRxiv · May 4, 2020Biophysics