Author

R. A. Weinberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

F. Reinhardt· 2 shared S. Iyer· 2 shared V. V. Phadnis· 2 shared W. S. Henry· 2 shared A. Deik· 1 shared A. E. Cohen· 1 shared A. Green· 1 shared A. Jo· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

F. Reinhardt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ether lipids influence cancer cell fate by modulating iron uptake

R. P. Mansell, S. Müller, J.-S. Yang, S. Innes-Gold, S. Das, F. Reinhardt, K. J. Sigmund, V. V. Phadnis, Z. Wan, J. Stark, D. Hwang, F. Sindikubwabo, L. Syx, N. Servant, E. N. Eaton, , W. S. Henry

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

bioRxiv · Mar 20, 2024Cancer Biology

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

H. Lee, D. M. Dinulescu, C. M. Castro, A. Jo, A. Green, J. E. Medina, S. Iyer, A. W. Ohman, E. T. McCarthy, F. Reinhardt, T. Gerton, D. Demehin, R. Mishra, D. L. Kolin, H. Zheng, , B. R. Reuda

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

bioRxiv · Jan 19, 2023 · PreprintCancer Biology

MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis

V. V. Phadnis, J. Snider, V. Wong, K. D. Vaccaro, T. Kunchok, J. Allen, Z. Yao, B. Geng, K. Weiskopf, I. Stagljar, W. S. Henry, R. A. Weinberg

This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.

bioRxiv · Sep 1, 2022Cell Biology

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

B. G. Neel, s. zhang, S. Iyer, H. Ran, W. wei, C. Foster, R. A. Weinberg

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.

bioRxiv · Apr 6, 2020Cancer Biology