Author

V. V. Phadnis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

R. A. Weinberg· 2 shared W. S. Henry· 2 shared A. Deik· 1 shared A. E. Cohen· 1 shared A. Viravalli· 1 shared B. Geng· 1 shared C. B. Clish· 1 shared D. A. A. Bonin· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

R. A. Weinberg

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Author profile →

3 papers

Recent·Most cited

Ether lipids influence cancer cell fate by modulating iron uptake

R. P. Mansell, S. Müller, J.-S. Yang, S. Innes-Gold, S. Das, F. Reinhardt, K. J. Sigmund, V. V. Phadnis, Z. Wan, J. Stark, D. Hwang, F. Sindikubwabo, L. Syx, N. Servant, E. N. Eaton, , W. S. Henry

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

bioRxiv · Mar 20, 2024Cancer Biology

MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis

V. V. Phadnis, J. Snider, V. Wong, K. D. Vaccaro, T. Kunchok, J. Allen, Z. Yao, B. Geng, K. Weiskopf, I. Stagljar, W. S. Henry, R. A. Weinberg

This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.

bioRxiv · Sep 1, 2022Cell Biology

Oncogenic role of a developmentally regulated NTRK2 splice variant

S. S. Pattwell, S. Arora, N. Nuechterlein, M. Zager, K. R. Loeb, P. J. Cimino, N. C. Holland, N. Reche-Ley, H. Bolouri, D. A. A. Bonin, F. Szulzewsky, V. V. Phadnis, T. Ozawa, M. J. Wagner, M. C. Haffner, , E. C. Holland

The paper identifies TrkB.T1, an embryonic NTRK2 splice variant, as an oncogenic driver in multiple tumor types across species, with distinct interactors in developmental and oncogenic pathways.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology