Nuclear morphology predicts cell survival to cisplatin chemotherapy
C.-J. Kim, A. L. Gonye, K. Truskowski, C.-F. Lee, R. Austin, K. J. Pienta, S. R. Amend
This study identifies nuclear morphology and functional characteristics associated with cancer cell survival after cisplatin chemotherapy, highlighting the role of the polyaneuploid cancer cell (PACC) state in treatment resistance.
bioRxiv · Sep 19, 2022Cancer Biology