ppGpp and RNA-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells
Y. Zhai, P. J. Minnick, J. P. Pribis, L. Garcia-Villada, P. J. Hastings, C. Herman, S. M. Rosenberg
The paper identifies the stringent starvation response as a key driver of ciprofloxacin-induced mutagenesis through RNA polymerase and ppGpp-mediated DNA-damage signaling.
bioRxiv · Jul 6, 2022Microbiology