N. Erez

Single-molecule systems for detection and monitoring of plasma circulating nucleosomes and oncoproteins in Diffuse Midline Glioma

This paper develops a single-molecule system to detect and monitor plasma nucleosomes and oncoproteins in Diffuse Midline Glioma patients, showing clinical utility for non-invasive diagnostics.

Monkeypox DNA correlates with virus infectivity in clinical samples

The paper correlates Monkeypox DNA content with virus infectivity in clinical samples and defines a PCR threshold for non-infectious virus.

Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics

The paper develops EPINUC, a single-molecule assay for analyzing plasma nucleosomes to detect cancer with high accuracy, including early-stage colorectal cancer and determining tumor origin.

Monitoring group activity of hamsters and mice as a novel tool to evaluate COVID-19 progression, convalescence and rVSV-ΔG-spike vaccination efficacy

This study uses group activity monitoring in hamsters and mice to assess SARS-CoV-2 infection, convalescence, and vaccine efficacy.

Nonclinical Safety and Immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs

This study evaluates the safety, immunogenicity, and efficacy of an rVSV-ΔG-SARS-CoV-2-S vaccine in multiple animal species, finding no adverse effects and a robust immune response.

MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease

This study shows that recombinant MVA vaccines expressing modified S proteins inhibit SARS-CoV-2 replication and prevent lethal disease in transgenic mice.

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from pre-mature aging

This study identifies Non-stop and its complex as regulators of enterocyte identity and aging in Drosophila, showing their role in maintaining chromatin accessibility and nuclear organization.

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

This study shows lung fibroblasts in breast cancer metastases are transcriptionally dynamic and plastic, with stage-specific gene signatures and Myc as a key regulator linked to poor survival.

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

Antiviral activity of Glucosylceramide synthase inhibitors against SARS-CoV-2 and other RNA virus infections

The study evaluates two GCS inhibitors for antiviral activity against four enveloped RNA viruses, including SARS-CoV-2, showing broad-spectrum efficacy and improved survival in infected mice.