Author

P. Purkayastha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

T. P. Lele· 3 shared K. Pendyala· 2 shared A. D. Hoefakker· 1 shared A. Majumder· 1 shared A. S. Saxena· 1 shared B. Yu· 1 shared C. F. Baer· 1 shared C. T. Halfmann· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

T. P. Lele

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability

K. L. Scott, C. T. Halfmann, A. D. Hoefakker, P. Purkayastha, T. C. Wang, T. P. Lele, K. Roux

The paper shows that changes in GTP availability, caused by cellular processes like migration, affect nucleocytoplasmic transport rates, impacting RNA export and protein synthesis.

bioRxiv · Dec 29, 2023Cell Biology

Rho activation drives luminal collapse and eversion in epithelial acini

V. Narayanan, P. Purkayastha, B. Yu, K. Pendyala, S. Chukkapalli, J. I. Cabe, R. B. Dickinson, D. E. Conway, T. P. Lele

This study shows that RhoA activation causes apical-out eversion in epithelial acini by altering mechanical homeostasis and surface tension differences.

bioRxiv · Jul 6, 2022Biophysics

Substrate stiffness controls the cell cycle of human mesenchymal stem cells via cellular traction

S. K. Kureel, S. Sinha, P. Purkayastha, S. Barretto, A. Majumder

This study shows that substrate stiffness between 1 and 5 kPa acts as a mechanical switch for hMSC cell cycle regulation via contractile forces, distinct from other cell types.

bioRxiv · Nov 19, 2021Bioengineering

Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblastspropagated on a novel soft substrate

P. Purkayastha, K. Pendyala, A. S. Saxena, H. Hakimjavadi, S. Chamala, P. D. Dixit, C. F. Baer, T. P. Lele

This study shows that reverse plasticity drives rapid evolution in fibroblasts adapted to soft substrates through genetic changes, not phenotypic plasticity alone.

bioRxiv · Apr 26, 2020 · PreprintEvolutionary Biology