Author

R. B. Dodd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Bruzas· 1 shared A. Buchanan· 1 shared A. P. Sergeeva· 1 shared A. Sigurdardottir· 1 shared A. Vilalta· 1 shared B. Honig· 1 shared D. A. Cannon· 1 shared D. G. Rees· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Bruzas

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

J. M. Sampson, D. A. Cannon, J. Duan, A. P. Sergeeva, J. C. K. Epstein, P. S. Katsamba, S. M. Mannepalli, F. A. Bahna, H. Adihou, S. M. Gueret, R. Gopalakrishnan, S. Geschwindner, D. G. Rees, A. Sigurdardottir, T. Wilkinson, , L. Wang

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

Journal of Molecular Biology · Aug 1, 2024Peer-reviewedBiophysics

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

A. Vilalta, Y. Zhou, J. Sevalle, J. K. Griffin, K. Sato, D. H. Allendorf, S. De, M. Puigdellivol, A. Bruzas, M. A. Burguillos, R. B. Dodd, F. Chen, Y. Zhang, P. Flagmeier, L.-M. Needham, , G. C. Brown

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

bioRxiv · Dec 3, 2020Biochemistry