Author

R. C. T. Wright

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 3 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1

Frequent Co-Authors

E. Harrison· 2 shared J. P. J. Hall· 2 shared J. Wood· 2 shared K. J. Muddiman· 2 shared M. A. Brockhurst· 2 shared M. Brockhurst· 2 shared S. Paterson· 2 shared C. E. Turner· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

E. Harrison

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Author profile →

4 papers

Recent·Most cited

Superiority of chromosomal compared to plasmid-encoded compensatory mutations

R. C. T. Wright, J. Wood, M. J. Bottery, K. J. Muddiman, S. Paterson, E. Harrison, M. A. Brockhurst, J. P. J. Hall

This study compares the ecological effects of compensatory mutations on plasmids and chromosomes, finding that chromosomal mutations are more effective in reducing plasmid fitness costs and promoting plasmid spread.

PLOS Biology · Dec 2, 2024Peer-reviewedMicrobiology

Multiple evolutionary pathways lead to vancomycin resistance in Clostridioides difficile

J. E. Buddle, R. C. T. Wright, C. E. Turner, R. R. Chaudhuri, M. A. Brockhurst, R. P. Fagan

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.

bioRxiv · Sep 15, 2023 · PreprintMicrobiology

Functional diversity increases the efficacy of phage combinations

R. C. T. Wright, V. Friman, M. C. M. Smith, M. Brockhurst

This study shows that phage combinations with higher functional diversity are more effective, allowing for simpler and more efficient phage therapies.

bioRxiv · Jul 9, 2021Microbiology

Plasmid fitness costs are caused by specific genetic conflicts

J. P. J. Hall, R. C. T. Wright, E. Harrison, K. J. Muddiman, J. Wood, S. Paterson, M. Brockhurst

The paper identifies specific genetic conflicts as the cause of plasmid fitness costs in Pseudomonas fluorescens, showing that single mutations can ameliorate these costs.

bioRxiv · Apr 10, 2021 · PreprintMicrobiology