Author

M. A. Brockhurst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:genome assembly· 1 Assay:metagenomics· 1

Frequent Co-Authors

E. Harrison· 2 shared J. P. J. Hall· 2 shared R. C. T. Wright· 2 shared S. Paterson· 2 shared C. E. Turner· 1 shared C. G. Knight· 1 shared C. Stevenson· 1 shared C. Winstanley· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

E. Harrison

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Superiority of chromosomal compared to plasmid-encoded compensatory mutations

R. C. T. Wright, J. Wood, M. J. Bottery, K. J. Muddiman, S. Paterson, E. Harrison, M. A. Brockhurst, J. P. J. Hall

This study compares the ecological effects of compensatory mutations on plasmids and chromosomes, finding that chromosomal mutations are more effective in reducing plasmid fitness costs and promoting plasmid spread.

PLOS Biology · Dec 2, 2024Peer-reviewedMicrobiology

Multiple evolutionary pathways lead to vancomycin resistance in Clostridioides difficile

J. E. Buddle, R. C. T. Wright, C. E. Turner, R. R. Chaudhuri, M. A. Brockhurst, R. P. Fagan

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.

bioRxiv · Sep 15, 2023 · PreprintMicrobiology

Horizontal gene transfer increases microbiome stability

K. Z. Coyte, C. Stevenson, C. G. Knight, E. Harrison, J. P. J. Hall, M. A. Brockhurst

This study shows that horizontal gene transfer increases microbiome stability by spreading resistance genes, but affects individual taxa differently based on gene mobility and community interactions.

bioRxiv · Feb 25, 2022 · PreprintEvolutionary Biology

Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations

S. O'Brien, R. Kummerli, S. Paterson, C. Winstanley, M. A. Brockhurst

This study shows transposable phages drive divergence in social strategies of Pseudomonas aeruginosa by promoting extreme siderophore production phenotypes in iron-limited environments.

bioRxiv · Mar 30, 2019Evolutionary Biology