R. R. Chaudhuri

This study shows that C. difficile can evolve vancomycin resistance through two pathways, but resistance comes with fitness costs and sporulation defects that may limit its clinical impact.

This paper shows that an intact S-layer in Clostridioides difficile enhances disease severity by analyzing revertants of an S-layer-null strain and their gene expression differences.

This study compares the genomes of Streptococcus pyogenes isolates from low- and high-income settings, revealing genetic diversity and differences in resistance genes and prophage content.

The paper uses transposon insertion sequencing to analyze the fitness landscape of Salmonella Typhimurium ST313 strain D23580, identifying essential genes and plasmid-encoded factors affecting growth and macrophage infection.

The paper compares genomic and transcriptomic differences between Salmonella ST313 and ST19 isolates to identify phenotypic variations and a novel plasmid maintenance system.