Author

R. D. Fagerlund

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. C. Fineran· 3 shared C. Garcia-Doval· 1 shared C. L. McCafferty· 1 shared C. M. Brown· 1 shared D. Mayo-Munoz· 1 shared D. W. Taylor· 1 shared E. A. Schwartz· 1 shared H. G. Hampton· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

P. C. Fineran

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection

D. Mayo-Munoz, L. M. Smith, C. Garcia-Doval, L. M. Malone, K. R. Harding, S. A. Jackson, H. G. Hampton, R. D. Fagerlund, L. F. Gumy, P. C. Fineran

The paper shows type III CRISPR-Cas systems provide immunity against jumbo phages by degrading bacterial DNA and disrupting phage replication through an accessory nuclease, leading to abortive infection.

bioRxiv · Jun 20, 2022Microbiology

Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex

E. A. Schwartz, J. P. Bravo, L. A. Macias, C. L. McCafferty, T. L. Dangerfield, J. N. Walker, J. S. Brodbelt, P. C. Fineran, R. D. Fagerlund, D. W. Taylor

The paper determines the structure of a type III-D CRISPR-Cas effector complex and characterizes its RNA cleavage mechanism, revealing how multi-subunit fusion proteins assemble into an active RNA endonuclease.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Discovery of multiple anti-CRISPRs uncovers anti-defense gene clustering in mobile genetic elements

R. Pinilla-Redondo, S. Shehreen, N. D. Marino, R. D. Fagerlund, C. M. Brown, S. J. Soerensen, P. C. Fineran, J. Bondy-Denomy

The paper identifies 11 new anti-CRISPR genes in Enterobacteriaceae and Pseudomonas, revealing their clustering with other anti-defense genes in genomic regions called 'anti-defense islands'.

bioRxiv · May 22, 2020Microbiology