Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus
A. Moon-Walker, Z. Zhang, D. S. Zyla, T. K. Buck, H. Li, R. Diaz Avalos, S. L. Schendel, K. M. Hastie, S. Crotty, E. O. Saphire
This study presents the cryoEM structure of LCMV surface glycoprotein and shows that the antibody M28 neutralizes the virus by stabilizing its prefusion state, offering a therapeutic candidate for LCMV infection.
bioRxiv · Jul 17, 2022Microbiology